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A toughness based deformation limit for X- and K-joints under brace axial tension

Bo GU,Xudong QIAN,Aziz AHMED

Frontiers of Structural and Civil Engineering 2016, Volume 10, Issue 3,   Pages 345-362 doi: 10.1007/s11709-016-0333-2

Abstract: This study reports a deformation limit for the initiation of ductile fracture failure in fatigue-cracked circular hollow section (CHS) X- and K-joints subjected to brace axial tension. The proposed approach sets the deformation limit as the numerically computed crack driving force in a fatigue crack at the hot-spot location in the tubular joint reaches the material fracture toughness measured from standard fracture specimens. The calibration of the numerical procedure predicates on reported numerical computations on the crack driving force and previously published verification study against large-scale CHS X-joints with fatigue generated surface cracks. The development of the deformation limit includes a normalization procedure, which covers a wide range of the geometric parameters and material toughness levels. The lower-bound deformation limits thus developed follow a linear relationship with respect to the crack-depth ratio for both X- and K-joints. Comparison of the predicated deformation limit against experimental on cracked tubular X- and K-joints demonstrates the conservative nature of the proposed deformation limit. The proposed deformation limit, when extrapolated to a zero crack depth, provides an estimate on the deformation limits for intact X- and K-joints under brace axial loads.

Keywords： circular hollow section (CHS)     tubular joint     fracture failure     deformation limit     <i>Ji>-integral    

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Elasto-plastic fatigue crack growth analysis of plane problems in the presence of flaws using XFEM

SHEDBALE,I. V. SINGH,B. K. MISHRA

Frontiers of Structural and Civil Engineering 2015, Volume 9, Issue 4,   Pages 420-440 doi: 10.1007/s11709-015-0305-y

Abstract: The -integral for two fracture modes (mode-I and mode-II) is obtained by decomposing the displacementtheir symmetric and antisymmetric parts, then individual stress intensity factors are extracted from -integral

Keywords： XFEM     von-Mises yield criterion     isotropic hardening     fatigue crack growth     <i>Ji>-integral    

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DDB1- and CUL4-associated factor 8 plays a critical role in spermatogenesis

Xiuli Zhang, Zhizhou Xia, Xingyu Lv, Donghe Li, Mingzhu Liu, Ruihong Zhang, Tong Ji, Ping Liu, Ruibao

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 302-312 doi: 10.1007/s11684-021-0851-8

Abstract: Cullin-RING E3 ubiquitin ligase (CRL)-4 is a member of the large CRL family in eukaryotes. It plays important roles in a wide range of cellular processes, organismal development, and physiological and pathological conditions. DDB1- and CUL4-associated factor 8 (DCAF8) is a WD40 repeat-containing protein, which serves as a substrate receptor for CRL4. The physiological role of DCAF8 is unknown. In this study, we constructed knockout mice. Homozygous mice were viable with no noticeable abnormalities. However, the fertility of deficient male mice was markedly impaired, consistent with the high expression of DCAF8 in adult mouse testis. Sperm movement characteristics, including progressive motility, path velocity, progressive velocity, and track speed, were significantly lower in knockout mice than in wild-type (WT) mice. However, the total motility was similar between WT and knockout sperm. More than 40% of spermatids in knockout mice showed pronounced morphological abnormalities with typical bent head malformation. The acrosome and nucleus of knockout sperm looked similar to those of WT sperm. tests showed that the fertilization rate of knockout mice was significantly reduced. The results demonstrated that DCAF8 plays a critical role in spermatogenesis, and DCAF8 is a key component of CRL4 function in the reproductive system.

Keywords： <i>Dcaf8i>     male infertility     spermatogenesis    

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Regulatory mechanism and functional analysis of

Yonglan Zhu,Fang Zhang,Shanzhen Zhang,Wanglong Deng,Huiyong Fan,Haiwei Wang,Ji Zhang

Frontiers of Medicine 2017, Volume 11, Issue 1,   Pages 87-96 doi: 10.1007/s11684-016-0469-4

Abstract:

S100A9, a calcium-binding protein, participates in the inflammatory process and development of various tumors, thus attracting much attention in the field of cancer biology. This study aimed to investigate the regulatory mechanism of and its function involvement in APL. We used real-time quantitative PCR to determine whether PML/RARα affects the expression of in NB4 and PR9 cells upon ATRA treatment. ChIP-based PCR and dual-luciferase reporter assay system were used to detect how PML/RARα and PU.1 regulate promoter activity. CCK-8 assay and flow cytometry were employed to observe the viability and apoptosis of NB4 cells when was overexpressed. Results showed that was an ATRA-responsive gene, and PML/RARα was necessary for the ATRA-induced expression of in APL cells. In addition, PU.1 could bind to the promoter of , especially when treated with ATRA in NB4 cells, and promote its activity. More importantly, overexpression of induced the apoptosis of NB4 cells and inhibited cell growth. Collectively, our data indicated that PML/RARα and PU.1 were necessary for the ATRA-induced expression of in APL cells. Furthermore, promoted apoptosis in APL cells and affected cell growth.

Keywords： S100A9 <i>S100A9i>     PU.1     PML/RARα     ATRA     APL    

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Effect of intestinal ischemia/reperfusion injury on leptin and orexin-A levels

LIN Ji, YAN Guangtao, HAO Xiuhua, ZHANG Kai, GAO Xiaoning, LIAO Jie

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 87-92 doi: 10.1007/s11684-007-0017-3

Abstract: ´) group decreased and that of I60´R360´ group increased., adipose leptin levels of I60´R30´ and I60´R90´ decreased, and adipose leptin in I60´R360´ group increasedAfter the injury, adipose leptin mRNA expressions of I60´R30´, I60´R240´ and I60´R360´ increased, whereasCompared with sham group, hypothalamus orexin-A mRNA expressions of I60´R30´ and I60´R90´ decreased graduallyafter the injury, with that of I60´R150´ group reaching the lowest, and those of I60´R240´ and I60´R360

Keywords： significant difference     intestinal I/R     transcriptase-polymerase     metabolic     central secretory    

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Trapezoidal Intuitionistic Fuzzy Aggregation Operator Based on Choquet Integral and Its Application to

Xi-hua Li,Xiao-hong Chen

Frontiers of Engineering Management 2015, Volume 2, Issue 3,   Pages 266-276 doi: 10.15302/J-FEM-2015048

Abstract: The Choquet integral can serve as a useful tool to aggregate interacting criteria in an uncertain environmentIn this paper, a trapezoidal intuitionistic fuzzy aggregation operator based on the Choquet integralA trapezoidal intuitionistic fuzzy aggregation operator based on the Choquet integral is then definedA new multi-criteria decision-making method based on a trapezoidal intuitionistic fuzzy Choquet integral

Keywords： multi-criteria decision making     trapezoidal intuitionistic fuzzy numbers     Choquet integral     fuzzy measure    

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Mesoscale fabrication of a complex surface for integral impeller blades

Xibin WANG,Tianfeng ZHOU,Lijing XIE,Li JIAO,Zhibing LIU,Zhiqiang LIANG,Pei YAN

Frontiers of Mechanical Engineering 2017, Volume 12, Issue 1,   Pages 116-131 doi: 10.1007/s11465-017-0426-1

Abstract:

Integral impeller is the most important component of a mini-engine.However, the machining of a mesoscale impeller with a complex integral surface is difficult because ofFor the fabrication of a complex integral impeller, a micro-ball-end mill is designed in accordance withSubsequently, fractal theory is applied to characterize the surface quality of the integral impeller.The fractal theory-based characterization shows that the completed mesoscale integral impeller exhibits

Keywords： mesoscale fabrication     micro-milling tool     mesoscale milling     impeller blade    

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Stability and coupling dynamic behavior of nonlinear journal active electromagnetic bearing rotor system

LU Yanjun, HEI Di, WANG Yuan, DAI Rong, LU Yanjun, LIU Heng, YU Lie

Frontiers of Mechanical Engineering 2008, Volume 3, Issue 2,   Pages 193-199 doi: 10.1007/s11465-008-0023-4

Abstract: system equations are formulated by combining equations for rotor motion and decentralized proportional integral

Keywords： proportional integral     bifurcation     corresponding     integral differential     predictor-corrector mechanism    

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Investigation on the integral output power model of a large-scale wind farm

BAO Nengsheng, MA Xiuqian, NI Weidou

Frontiers in Energy 2007, Volume 1, Issue 1,   Pages 67-78 doi: 10.1007/s11708-007-0006-x

Abstract: The integral output power model of a large-scale wind farm is needed when estimating the wind farm sThe calculation algorithms and steps of the integral output power model of a large-scale wind farm are

Keywords： power model     actual     energy     large-scale     practical measurement    

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Mass Spectrometry Analysis of Newly Emerging Coronavirus HCoV-19 Spike Protein and Human ACE2 Reveals Camouflaging Glycans and Unique Post-Translational Modifications Article

Zeyu Sun, Keyi Ren, Xing Zhang, Jinghua Chen, Zhengyi Jiang, Jing Jiang, Feiyang Ji, Xiaoxi Ouyang, Lanjuan

Engineering 2021, Volume 7, Issue 10,   Pages 1441-1451 doi: 10.1016/j.eng.2020.07.014

Abstract: All seven glycosylation sites in human angiotensin I converting enzyme 2 (hACE2) were found to be completely

Keywords： <i>Ni>-glycosylation     COVID-19     Spike protein     hACE2     Structure    

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Modeling of specific structure crystallization coupling with dissolution

Yuanhui JI, Hongliang QIAN, Chang LIU, Xiaohua LU, Xin FENG, Xiaoyan JI,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1,   Pages 52-56 doi: 10.1007/s11705-009-0301-7

Abstract: In this paper, the research framework for specific structure crystallization modeling has been proposed in which four steps are required in order to investigate the rigorous crystallization modeling by thermodynamics. The first is the activity coefficient model of the solution, the second is Solid-Liquid equilibrium, the third and fourth are the dissolution and crystallization kinetics modeling, respectively. Our investigations show that the mechanisms of complex structure formation and microphase transition can be analyzed by combining the dissolution and crystallization kinetics modeling. Moreover, the formation mechanism of the porous KCl has been analyzed, which may provide a reference for the porous structure formation in the advanced material synthesis.

Keywords： structure crystallization     activity coefficient     reference     KCl     dissolution    

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Intelligent fractional-order integral sliding mode control for PMSM based on an improved cascade observer Research Articles

Lingfei XIAO, Leiming MA, Xinhao HUANG,lfxiao@nuaa.edu.cn

Frontiers of Information Technology & Electronic Engineering 2022, Volume 23, Issue 2,   Pages 328-338 doi: 10.1631/FITEE.2000317

Abstract: The proposed FOISMC strategy associates strong points of the integral action (which can eliminate steady-state

Keywords： Permanent magnet synchronous motor     Fractional-order integral sliding mode     Optimization algorithm     Sensorless    

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Solution of Integral Equations and Experimental Analysis of Fire Smoke Plumes in Stably Linearly Thermally

Fang Jun,Shu Xueming,Yuan Hongyong,Zheng Xin

Strategic Study of CAE 2004, Volume 6, Issue 1,   Pages 37-43

Abstract:

Through numerical solution of the dimensionless integral equations of the turbulent buoyant plumecalculation results and the empirical formula in the available literatures, thus this work validates the integral

Keywords： stably linearly thermally stratified environment     fire smoke plume     solution of integral equations     experimental    

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Shao-ji Luo: a Brief Biography

Shi-qian Hu,Liang-liang Jia

Frontiers of Engineering Management 2016, Volume 3, Issue 4,   Pages 414-415 doi: 10.15302/J-FEM-2016062

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Heavy vehicle dynamics with balanced suspension based on enveloping tire model

Yongjie LU, Shaopu YANG, Shaohua LI

Frontiers of Mechanical Engineering 2010, Volume 5, Issue 4,   Pages 476-482 doi: 10.1007/s11465-010-0120-z

Abstract: Based on D’Alembert principle, an integral balanced suspension (IBS) model is established, considering

Keywords： heavy vehicle     integral balanced suspension     enveloping properties     ride comfort     road-friendliness    

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Title Author Date Type Operation

A toughness based deformation limit for X- and K-joints under brace axial tension

Bo GU,Xudong QIAN,Aziz AHMED

Journal Article

Elasto-plastic fatigue crack growth analysis of plane problems in the presence of flaws using XFEM

SHEDBALE,I. V. SINGH,B. K. MISHRA

Journal Article

DDB1- and CUL4-associated factor 8 plays a critical role in spermatogenesis

Xiuli Zhang, Zhizhou Xia, Xingyu Lv, Donghe Li, Mingzhu Liu, Ruihong Zhang, Tong Ji, Ping Liu, Ruibao

Journal Article

Regulatory mechanism and functional analysis of

Yonglan Zhu,Fang Zhang,Shanzhen Zhang,Wanglong Deng,Huiyong Fan,Haiwei Wang,Ji Zhang

Journal Article

Effect of intestinal ischemia/reperfusion injury on leptin and orexin-A levels

LIN Ji, YAN Guangtao, HAO Xiuhua, ZHANG Kai, GAO Xiaoning, LIAO Jie

Journal Article

Trapezoidal Intuitionistic Fuzzy Aggregation Operator Based on Choquet Integral and Its Application to

Xi-hua Li,Xiao-hong Chen

Journal Article

Mesoscale fabrication of a complex surface for integral impeller blades

Xibin WANG,Tianfeng ZHOU,Lijing XIE,Li JIAO,Zhibing LIU,Zhiqiang LIANG,Pei YAN

Journal Article

Stability and coupling dynamic behavior of nonlinear journal active electromagnetic bearing rotor system

LU Yanjun, HEI Di, WANG Yuan, DAI Rong, LU Yanjun, LIU Heng, YU Lie

Journal Article

Investigation on the integral output power model of a large-scale wind farm

BAO Nengsheng, MA Xiuqian, NI Weidou

Journal Article

Mass Spectrometry Analysis of Newly Emerging Coronavirus HCoV-19 Spike Protein and Human ACE2 Reveals Camouflaging Glycans and Unique Post-Translational Modifications

Zeyu Sun, Keyi Ren, Xing Zhang, Jinghua Chen, Zhengyi Jiang, Jing Jiang, Feiyang Ji, Xiaoxi Ouyang, Lanjuan

Journal Article

Modeling of specific structure crystallization coupling with dissolution

Yuanhui JI, Hongliang QIAN, Chang LIU, Xiaohua LU, Xin FENG, Xiaoyan JI,

Journal Article

Intelligent fractional-order integral sliding mode control for PMSM based on an improved cascade observer

Lingfei XIAO, Leiming MA, Xinhao HUANG,lfxiao@nuaa.edu.cn

Journal Article

Solution of Integral Equations and Experimental Analysis of Fire Smoke Plumes in Stably Linearly Thermally

Fang Jun,Shu Xueming,Yuan Hongyong,Zheng Xin

Journal Article

Shao-ji Luo: a Brief Biography

Shi-qian Hu,Liang-liang Jia

Journal Article

Heavy vehicle dynamics with balanced suspension based on enveloping tire model

Yongjie LU, Shaopu YANG, Shaohua LI

Journal Article